Sub-cortical Dementia

Dementia infantilis with cortical dysrhythmia.

Dementia and the major psychoses are rare in children. Weygandt, in 1907, introduced the term dementia infantilis to describe cases of progressive mental deterioration of obscure causation, occurring in young children whose previous development had been normal. Since then many of the cases to which this description applies have been found to have a definite etiology in in-flammatory, degenerati...

Comparative neuropsychology of cortical and subcortical dementia.

The terms "cortical" and "subcortical" dementia are controversial; however, the clinical distinction between them is real. For example, although Alzheimer's and Parkinson's disease (prototypical of cortical and subcortical dementia, respectively) share clinical features, they differ in the presence of aphasia, apraxia, and agnosia in Alzheimer's disease but not in Parkinson's dementia. We revie...

Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons

Understanding the basis of brain function requires knowledge of cortical operations over wide-spatial scales, but also within the context of single neurons. In vivo, wide-field GCaMP imaging and sub-cortical/cortical cellular electrophysiology were used in mice to investigate relationships between spontaneous single neuron spiking and mesoscopic cortical activity. We make use of a rich set of c...

Epidemiology of Dementia among the Elderly in Sub-Saharan Africa

Objectives. To review epidemiologic studies on the prevalence, incidence, and risk factors of dementia in sub-Saharan Africa (SSA). Methods. A MEDLINE search (from January 1992 to December 31, 2013) of epidemiologic studies, with no language restriction, was conducted using the keywords "dementia" or "Alzheimer's" and "Africa." We selected for review population and hospital-based studies that r...

Dementia in sub-Saharan Africa: Challenges and opportunities